The research technician will be involved and trained in techniques relevant to our translational research program exploring the human immune response to tuberculosis. The focus will be on identifying antibody responses to M. tuberculosis antigens that could serve as biomarkers or correlates of protection against TB. This will include techniques such as the culturing of mycobacteria, the production of antigens, human sample preparations, data recording, and the performance and analysis of antibody detection assays such as immunoblots, ELISAs, and microarrays. In addition, the technician will help with breeding a colony of humanized mice, and will specifically be involved in genotyping offspring.
The person will:
*May not be applicable.
Dr. Achkar is an NIH-funded physician scientist who is specialized in Infectious Diseases with an additional master’s degree in clinical research methods. Her translational research program is focused on the evaluation of immune and other host responses to Mycobacterium tuberculosis in patients at various states of infection towards i) the development of better serodiagnostic tests for active tuberculosis (TB); ii) the prediction of TB development in HIV+ subjects; iii) the study of protective antibody functions against M. tuberculosis; and iv) the identification of host responses that correlate with TB vaccine effectiveness. Dr. Achkar has several national and international collaborations with investigators from a broad range of expertise in areas such as clinical trials/research, biodesign, biochemistry, epidemiology, and biostatistics. As a specialist in Infectious Diseases with a master’s in clinical research methods, Dr. Achkar analyzes her laboratory data in the context of clinical findings to contribute critical data to the field of TB diagnostics, immunotherapy, and vaccine development.